Ameritox

Clinical Research

Ameritox’s clinical research program identifies and investigates key topics related to managing patients on chronic opioid therapy. This research adds to the body of knowledge on the subject of managing these chronic pain patients, contributes to better outcomes in pain management and allows Ameritox to expand the tools and resources we offer to our clinician partners.

Our research team collaborates with top academic, research, and pain centers, including Beth Israel Medical Center and Thomas Jefferson School of Population Health, and we lead the industry with an innovative research program that’s redefining the field of pain medication monitoring.

Explore Ameritox research contributions below.

Peer-Reviewed Publications

Healthcare costs and nonadherence among chronic opioid users
Leider, H.L., et. al., American Journal of Managed Care (2011)
This study assessed the health economic burden of chronic opioid users and determined whether potential opioid regimen nonadherence is associated with increased healthcare costs. The study concludes that patients on chronic opioid therapy who were likely to be nonadherent to their prescription regimens, according to urine drug monitoring results, had significantly higher overall healthcare costs than patients who are likely adherent to their prescription regimen.
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Using an algorithm applied to urine drug screening to assess adherence to a hydrocodone regimen
Couto, J.E., et. al., Journal of Clinical Pharmacy and Therapeutics (2010)
This study examined variation in standard and normalized urine drug levels in healthy adult volunteers on low, medium, and high doses of hydrocodone. Normalized urine drug levels were derived from a proprietary algorithm that was part of Ameritox’s Rx GuaridanSM process prior to the launch of Rx Guardian CDSM.
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Determination of tapentadol (Nucynta) and N-Desmethyltapentadol in authentic urine specimens by ultra-performance liquid chromatography-tandem mass spectrometry
Bourland, J.A., et. al., Journal of Analytical Toxicology (2010)
Urine specimens from pain management patients taking tapentadol (Nucynta) were confirmed for the presence of tapentadol and N-desmethyltapentadol using ultra-performance liquid chromatography–tandem mass spectrometry to minimize sample preparation and urine volume requirements. The presence of significant N-desmethyltapentadol glucuronide was demonstrated for the first time.
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High Rates of inappropriate drug use in the chronic pain population

Couto, J.E., et. al., Population Health Management (2009)
A retrospective analysis of results of nearly one million urine drug tests conducted over a three-year period examined the rates of potential drug misuse, abuse, and non-adherence in a population of patients who were prescribed chronic opioids.
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Use of an algorithm applied to urine drug screening to assess adherence to an OxyContin regimen
Couto, J.E., et. al., Journal of Opioid Management (2009)
This study examined variation in standard and normalized urine drug levels in healthy adult volunteers on low, medium, and high doses of OxyContin(r). Normalized urine drug levels were derived from a proprietary algorithm that was part of Ameritox’s Rx GuaridanSM process prior to the launch of Rx Guardian CDSM.
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Abstracts and Poster Presentations

Rx Amphetamine Misuse in Pain Patients
Poster Presentation, Pain Week
Location:  Las Vegas, NV
Dates:  September 4-6, 2013
Authors: Ko M,  Keats M, DeGeorge M, Dawson E, Woster P, Bronstein K

Suboxone Poster
Poster Presentation, American Academy of Pain Management
Location:  Orlando, FL
Dates:  September 26 – 29, 2013
Authors:  DeGeorge M, Dawson E, Woster P, Ko M, Bronstein K

An analysis of the association between marijuana use and potential nonadherence in patients prescribed hydrocodone
Poster Presentation, American Academy of Pain Medicine
Location: Ft. Lauderdale, FL
Dates: April 10-14, 2013
Authors: DeGeorge M, Dawson E, Woster P, Ko M, Burke L, Bronstein K

Analysis of illicit substance abuse and medication monitoring by payer type
Poster Presentation, PAINWeek
Location: Las Vegas, NV
Dates: September 5-8, 2012
Authors: Burke L, Dawson E, DeGeorge M, et al.

Patterns of Drug Use in the Older Chronic Pain Population
Poster Presentation, 31st Annual Scientific Meeting of the American Pain Society
Location: Honolulu, HI
Dates: May 16-19, 2012
Authors: Burke, L., Fay, M.

Using quantitative urine drug levels to monitor adherence in chronic opioid therapy: Comparison across two pain populations
Poster Presentation, PAINWeek
Location: Las Vegas, NV
Dates: September 7-10, 2011
Authors: Portenoy, R., et. al.

Can clinicians accurately predict which patients are misusing their medications?
Poster Presentation, 30th Annual Scientific Meeting of the American Pain Society
Location: Austin, TX
Dates: May 19-21, 2011.
Authors: Bronstein, K., et. al.

Rates of inappropriate drug use in the chronic pain population: an update.

Poster Presentation, 30th Annual Scientific Meeting of the American Pain Society
Location: Austin, TX
Dates: May 19-21, 2011.
Authors: Bronstein, K., et. al.

Pain medication monitoring using urine drug testing in an internal medicine practice: can it impact clinical decisions?
Poster Presentation, 30th Annual Scientific Meeting of the American Pain Society
Location: Austin, TX
Dates: May 19-21, 2011.
Authors: Bronstein, K., et. al.

Predicting abnormal urine drug testing in patients on chronic opioid therapy.
Poster Presentation, PAIN Week
Location: Las Vegas, NV
Dates: September 8-11, 2010.
Authors: Bronstein, K., et. al.

Health care utilization and costs associated with nonadherence to a chronic opioid regimen.
Poster Presentation, Academy of Managed Care Pharmacy Annual Meeting
Location: San Diego, CA
Dates: April 7-10, 2010.
Authors: Leider, H.L., et. al.

Chronic opioid adherence and health care costs in a managed care population.
Poster Presentation, American Academy of Pain Medicine 26th Annual International Meeting
Location: San Antonio, TX
Dates: February 3-6, 2010
Authors: Leider, H.L., et. al.

Importance of routine urine drug testing in the chronic pain patient population.
Poster Presentation, the International Society of Pharmacoeconomics and Outcomes Research
Location: Orlando, FL
Dates: May 16-20, 2009.
Authors: Couto, J.E., et. al.