Transmucosal, Oral Opioids Found to be Concordant for Breakthrough Pain in Opioid-Tolerant Patients with Chronic Pain

Determining an effective opioid dose for chronic pain in patients who become opioid tolerant can be challenging. In fact, effective dosing of a rapid-onset transmucosal opioid for breakthrough pain is not related to the around-the-clock dose, studies have shown. However, few data exist on the effective dose of the more traditional, short-acting oral opioids.

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